Allentown Central Catholic High School is a member of the Eastern Pennsylvania Conference (EPC18). 

This conference is comprised of 18 member high schools formerly affiliated with the Lehigh Valley Interscholastic Athletic Conference and the Mountain Valley Conference. The principals of the Eastern Pennsylvania Conference is to serve and unite local schools and communities through academic and athletic competition. The EPC18 places athletics in its proper perspective as a compliment to the academic program. Members of the EPC18 are committed to maximizing instructional time, promoting good sportsmanship and promoting equal and fair competition for all member schools.